研究领域：（1）环境污染物的生物监测；（2）环境污染物暴露的人群健康效应（环境分子流行病学）；（3）环境污染物的分子毒理机制（环境毒理学）；（4）暴露和效应生物标志物的筛选与应用。
研究组成员：
副研究员（组长）：黄清育（qyhuang@iue.ac.cn）
副研究员：田美平（mptian@iue.ac.cn）
在读研究生：
博士生：张西、杜晓妍、南冰茹、Alam
硕士生：高洪影、韩薛婧娉、李富萍、曹美宜
科研项目：
1. 国家自然科学基金面上项目：代谢和组蛋白修饰共调控在砷暴露致学习记忆障碍中的作用机制研究（22076179）
2. 国家自然科学基金面上项目：表观遗传调控在PFCs干扰雄性生殖内分泌中的作用机制（21677142）
3. 国家自然科学基金青年基金项目：砷暴露对精子组蛋白修饰的影响及其男（雄）性生殖毒性机制研究（21307127）
4. 国家自然科学基金青年基金项目：邻苯二甲酸酯侧链长度与雄性生殖毒性的相关性及分子机制研究（21307126）
5. 福建省自然科学基金面上项目：组蛋白修饰在PFOS干扰睾丸类固醇激素合成中的作用机制研究（2019J01138）
6. 福建省自然科学基金面上项目：基于表观遗传（组蛋白修饰）的 PM2.5雄性生殖毒性机制研究（2015J01066）
7. 福建省自然科学基金面上项目：谷胱甘肽转移酶家族基因（表观）遗传因素及典型环境致癌物暴露与肝癌易感性研究（2017J0102）
8. 中国科学院城市环境研究所青年人才领域前沿项目：慢性PM2.5暴露对机体内源性代谢物的影响及其诱发代谢紊乱相关疾病的风险研究（IUEQN201301）
近五年代表论著：
1. Huang Q*, Liu L, Wu Y, Wang X, Luo L, Nan B, Zhang J, Tian M, Shen H. Seminal plasma metabolites mediate the associations of multiple environmental pollutants with semen quality in Chinese men. Environ. Int. 2019, 132: 105066.
2. Huang Q, Hu D, Wang X, Chen Y, Wu Y, Pan L, Li H, Zhang J, Deng F, Guo X, Shen H. The modification of indoor PM2.5 exposure to chronic obstructive pulmonary disease in Chinese elderly people: A meet-in-metabolite analysis. Environ. Int. 2018, 121: 1243-1252.
3. Huang Q, Xi G, Alamdar A, Zhang J, Shen H. Comparative proteomic analysis reveals heart toxicity induced by chronic arsenic exposure in rats. Environ. Pollut. 2017, 229: 210-218.
4. Alamdar A, Tian M, Huang Q*, Du X, Zhang J, Liu L, Shah STA, Shen H. Enhanced histone H3K9 tri-methylation suppresses steroidogenesis in rat testis chronically exposed to arsenic. Ecotoxicol. Environ. Saf. 2019, 170: 513-520.
5. Alamdar A, Xi G, Huang Q*, Tian M, Eqani SAMAS, Shen H. Arsenic activates the expression of 3β-HSD in mouse Leydig cells through repression of histone H3K9 methylation. Toxicol. Appl. Pharmacol. 2017, 326: 7-14.
6. Huang Q*, Luo L, Alamdar A, Zhang J, Liu L, Tian M, Eqani SA, Shen H. Integrated proteomics and metabolomics analysis of rat testis: Mechanism of arsenic-induced male reproductive toxicity. Sci. Rep. 2016, 6: 32518.
7. Meiping Tian*, Benhua Zhao, Francis L. Martin, Camilo L.M. Morais, Liangpo Liu, Qingyu Huang, Heqing Shen*. Gene-environment interactions between GSTs polymorphisms and targeted epigenetic alterations in hepatocellular carcinoma following organochlorine pesticides (OCPs) exposure. Environment International 2020, 105313.
8. Meiping Tian, Liangpo Liu, Jie Zhang, Qingyu Huang, Heqing Shen. Positive association of low-level environmental phthalate exposure with sperm motility was mediated by DNA methylation: A pilot study. Chemosphere 2019, 220: 459-467.
9. Meiping Tian*, Xi Zhang, Liangpo Liu, Heng Wang, Jie Zhang, Qingyu Huang, Heqing Shen. Phthalate side chain structures and hydrolysis metabolism associated with their steroidogenesis effects in MLTC-1 Leydig cells. Toxicology letters 2019, 308: 56-64.
10. Meiping Tian, Qingyu Huang, Heng Wang, Francis L Martin, Liangpo Liu, Jie Zhang, Heqing Shen. Biphasic effects of perfluorooctanoic acid on steroidogenesis in mouse Leydig tumor cells. Reproductive Toxicology 2019, 83: 54-62.
11. Meiping Tian, Liangpo Liu, Heng Wang, Xiaofei Wang, Francis L. Martin, Jie Zhang, Qingyu Huang, Liangpo Liu, Heqing Shen. Phthalates induce androgenic effects at exposure levels that can be environmentally relevant in humans. Environmental Science & Technology Letters 2018, 5: 232-236.
12. Meiping Tian, Benhua Zhao, Jie Zhang, Francis L. Martin, Qingyu Huang, Liangpo Liu, Heqing Shen. Association of environmental benzo[a]pyrene exposure and DNA methylation alterations in hepatocellular carcinoma: A Chinese case-control study. Science of the Total Environment 2016, 541: 1243-1252.
