崔丽：中国科学院城市环境研究所，研究员，博导，国家优青。厦门大学学士和博士，英国牛津大学、兰卡斯特大学和瑞士伯尔尼大学访问学者。长期从事环境微生物单细胞拉曼新技术研发，并研究原位复杂环境中抗生素耐药性、病原菌、以及固氮和解磷等有益功能菌。已在PNAS，Angew，JACS，PNAS nexus，EST，Anal Chem等发表论文70余篇，应邀在Anal Chem和Trends in Anal Chem发表拉曼研究微生物的方法综述。担任美国微生物学会旗下杂志mSystems编辑，Chinese Chem lett、环境化学等编委。主持NSFC国家优青基金、微塑料专项项目、重大研究计划，以及中国科学院从0到1原始创新项目等10余项，参与NSFC创新群体研究项目。
环境生物分析化学，尤其是发展和利用单细胞拉曼/表面增强拉曼光谱，及其与稳定同位素标记和分子生物学的联用技术，开展环境微生物的研究，如抗生素抗性、氮磷微生物利用过程、生物膜、纳米毒性、微塑料及附着微生物和生物膜等
1. Li, H. Z.; Yang, K.; Liao, H.; Lassen, S. B.; Su, J. Q.; Zhang, X.; Cui, L*.; Zhu, Y. G*., Active antibiotic resistome in soils unraveled by single-cell isotope probing and targeted metagenomics. Proc. Natl. Acad. Sci. U. S. A. 2022, 119, (40), e2201473119.
2. Yang, K.; Xu, F.; Zhu, L.; Li, H.; Sun, Q.; Yan, A.; Ren, B.; Zhu, Y. G.; Cui, L*., An Isotope-Labeled Single-Cell Raman Spectroscopy Approach for Tracking the Physiological Evolution Trajectory of Bacteria toward Antibiotic Resistance. Angew. Chem. Int. Ed. 2023, 62, (14), e202217412.
3. Cui, L*#.; Xin, Y#.; Yang, K#.; Li, H.; Tan, F.; Zhang, Y.; Li, X.; Zhu, Z.; Yang, J.; Kao, S.-J.; Ren, B.; Zhu, Y.-G.; Musat, F.; Musat, N., Live tracking metabolic networks and physiological responses within microbial assemblages at single-cell level. PNAS nexus 2023, 2, (3), 1-12.
4. Qin, Y.; Shi, Z.; Zhu, L.; Li, H.; Lu, W.; Ye, G.; Huang, Q.; Cui, L*., Impact of Airborne Pathogen-Derived Extracellular Vesicles on Macrophages Revealed by Raman Spectroscopy and Multiomics. Environ. Sci. Technol. 2023, 57, (42), 15858-15868.
5. Qin, Y. F.; Guo, Z. H.; Huang, H. N.; Zhu, L. T.; Dong, S. J.; Zhu, Y. G.; Cui, L*.; Huang, Q. S*., Widespread of Potential Pathogen-Derived Extracellular Vesicles Carrying Antibiotic Resistance Genes in Indoor Dust. Environ. Sci. Technol. 2022, 56, (9), 5653-5663.
6. Zhu, L.; Li, R.; Yang, K.; Xu, F.; Lin, C.; Chen, Q.; Zhu, D.; Sun, Q.; Zhu, Y. G.; Cui, L*., Quantifying health risks of plastisphere antibiotic resistome and deciphering driving mechanisms in an urbanizing watershed. Water Res. 2023, 245, 120574.
7. Li, H.-Z.; Ding, J.-Z.; Xu, F.; Zhu, L.-J.; Cui, L*., Single‐cell Raman and functional gene analyses reveal microbial P solubilization in agriculture waste‐modified soils. mlife 2022, 2, (2), 190-200.
8. Cui, L.*; Li, H.-Z.; Yang, K.; Zhu, L.-J.; Xu, F.; Zhu, Y.-G., Raman biosensor and molecular tools for integrated monitoring of pathogens and antimicrobial resistance in wastewater Trac-Trend Anal Chem 2021, 143, 116415.
9. Chen, Q.-L.; Hu, H.-W.; He, Z.-Y.; Cui, L.; Zhu, Y.-G.; He, J.-Z., Potential of indigenous crop microbiomes for sustainable agriculture Nat Food 2021, 2, 233-240.
10. Morais, C. L. M.; Paraskevaidi, M.; Cui, L.; Fullwood, N. J.; Isabelle, M.; Lima, K. M. G.; Martin-Hirsch, P. L.; Sreedhar, H.; Trevisan, J.; Walsh, M. J.; Zhang, D.; Zhu, Y. G.; Martin, F. L., Standardization of complex biologically derived spectrochemical datasets. Nat Protoc 2019, 14, (5), 1546-1577.
11. Li, R.; Zhu, L.; Yang, K.; Li, H.; Zhu, Y.-G.; Cui, L*., Impact of urbanization on antibiotic resistome in different microplastics: evidence from a large-scale whole river analysis. Environ. Sci. Technol. 2021, 55, (13), 8760-8770.
12. Li, H. Z.; Zhu, D.; Lindhardt, J. H.; Lin, S. M.; Ke, X.; Cui, L., Long-Term Fertilization History Alters Effects of Microplastics on Soil Properties, Microbial Communities, and Functions in Diverse Farmland Ecosystem. Environ. Sci. Technol. 2021, 55, (8), 4658-4668.
13. Yang, K.; Chen, Q. L.; Chen, M. L.; Li, H. Z.; Liao, H.; Pu, Q.; Zhu, Y. G.; Cui, L*., Temporal Dynamics of Antibiotic Resistome in the Plastisphere during Microbial Colonization. Environ. Sci. Technol. 2020, 54, (18), 11322-11332.
14. Li, H.-Z.; Zhang, D.; Yang, K.; An, X.-L.; Pu, Q.; Lin, S.-M.; Su, J.-Q.; Cui, L*., Phenotypic Tracking of Antibiotic Resistance Spread via Transformation from Environment to Clinic by Reverse D2O Single-Cell Raman Probing. Anal. Chem. 2020, 92, (23), 15472-15479.
15. Yang, K.; Li, H. Z.; Zhu, X.; Su, J. Q.; Ren, B.; Zhu, Y. G.; Cui, L*., Rapid Antibiotic Susceptibility Testing of Pathogenic Bacteria Using Heavy-Water-Labeled Single-Cell Raman Spectroscopy in Clinical Samples. Anal. Chem. 2019, 91, 6296-6303.
16. Li, H.-Z.; Bi, Q.-f.; Yang, K.; Zheng, B.-X.; Pu, Q.; Cui, L*., D2O-Isotope-Labeling Approach to Probing Phosphate-Solubilizing Bacteria in Complex Soil Communities by Single-Cell Raman Spectroscopy. Anal. Chem. 2019, 91, (33), 2239-2246.
17. Chen, Q. L.; Zhu, D.; An, X. L.; Ding, J.; Zhu, Y. G.; Cui, L.*, Does nano silver promote the selection of antibiotic resistance genes in soil and plant? Environ Int 2019, 128, 399-406.
18. Cui, L.; Yang, K.; Li, H.-Z.; Zhang, H.; Su, J.-Q.; Paraskevaidi, M.; Martin, F. L.; Ren, B.; Zhu, Y.-G.*, A novel functional single-cell approach to probing nitrogen-fixing bacteria in soil communities by resonance Raman spectroscopy with 15N2 labelling. Anal. Chem. 2018, 90, 5082-5089.
19. Cui, L*.; Yang, K.; Zhou, G.; Huang, W. E*; Zhu, Y. G., Surface-enhanced Raman spectroscopy combined with stable isotope probing to monitor nitrogen assimilation at both bulk and single-cell level. Anal. Chem. 2017, 89, (11), 5793-5800.
20. Chen, Q. L.; An, X. L.; Zhu, Y. G.; Su, J. Q.; Gillings, M. R.; Ye, Z. L.; Cui, L.*, Application of Struvite Alters the Antibiotic Resistome in Soil, Rhizosphere, and Phyllosphere. Environ. Sci. Technol. 2017, 51, (14), 8149-8157.
21. Wang, Y.; Huang, W. E*.; Cui, L.; Wagner, M., Single cell stable isotope probing in microbiology using Raman microspectroscopy. Curr. Opin. Biotechnol. 2016, 41, 34-42.
22. Cui, L.; Zhang, Y.-J.; Huang, W. E.; Zhang, B.-F. M., Francis L; Li, J.-Y.; Zhang, K.-S.; Zhu, Y.-G.*, Surface-Enhanced Raman Spectroscopy for Identification of Heavy Metal Arsenic(V)-Mediated Enhancing Effect on Antibiotic Resistance. Anal. Chem. 2016, 88, (6), 3164–3170.
23. Cui, L.*; Chen, P.; Zhang, B.; Zhang, D.; Li, J.; Martin, F. L.; Zhang, K.*, Interrogating chemical variation via layer-by-layer SERS during biofouling and cleaning of nanofiltration membranes with further investigations into cleaning efficiency. Water Res. 2015, 87, 282-291.
24. Cui, L.*, Chen, P., Chen, S., Yuan, Z., Yu, C., Ren, B. and Zhang, K.*,. In Situ Study of the Antibacterial Activity and Mechanism of Action of Silver Nanoparticles by Surface-Enhanced Raman Spectroscopy. Anal. Chem. 2013, 85(11), 5436-5443.
25. Song, Y.#; Cui, L.#; Lopez, J. A. S.; Xu, J.; Zhu, Y. G.; Thompson, I. P.; Huang, W. E*., Raman-Deuterium Isotope Probing for in-situ identification of antimicrobial resistant bacteria in Thames River. Sci Rep 2017, 7, (1), 16648
26. Chen, Q.-L.; Fan, X.-T.; Zhu, D.; An, X.-L.; Su, J.-Q.; Cui, L*., Effect of biochar amendment on the alleviation of antibiotic resistance in soil and phyllosphere of Brassica chinensis L. Soil Biol. Biochem. 2018, 119, 74-82.
27. Chen, Q. L.; An, X. L.; Li, H.; Zhu, Y. G.; Su, J. Q.; Cui, L.*, Do manure-borne or indigenous soil microorganisms influence the spread of antibiotic resistance genes in manured soil? Soil Biol. Biochem. 2017, 114, 229-237.
28. Chen, P. Y.; Cui, L.*; Zhang, K. S.*, Surface-enhanced Raman spectroscopy monitoring the development of dual-species biofouling on membrane surfaces. J. Membr. Sci. 2015, 473, 36–44.
29. K？gler, M.*; Zhang, B. F.; Cui, L.*; Shi, Y. J.; Yliperttula, M.; Laaksonen, T.; Viitala, T.; Zhang, K., Real-time Raman based approach for identification of biofouling. Sensors and Actuators B: Chemical 2016, 230, 411-421.
30. Zhang, B.; Cui, L.*; Zhang, K.*, Dosage- and time-dependent antibacterial effect of zinc oxide nanoparticles determined by a highly uniform SERS negating undesired spectral variation. Anal Bioanal Chem 2016, 408, (14), 3853-65.
31. Cui, L.*; Butler, H. J.; Martin-Hirsch, P. L.; Martin, F. L.*, Aluminium foil as a potential substrate for ATR-FTIR, transflection FTIR or Raman spectrochemical analysis of biological specimens. Anal Methods-Uk 2016, 8, 481-487.
32. Cui, L., Liu, B., Vonlanthen, D., Mayor, M., Fu, Y.C., Li, J.F. and Wandlowski, T.*, In Situ Gap-Mode Raman Spectroscopy on Single-Crystal Au(100) Electrodes: Tuning the Torsion Angle of 4,4 '-Biphenyldithiols by an Electrochemical Gate Field. J. Am. Chem. Soc. 2011, 133(19), 7332-7335.
33. Cui, L., Yao, M., Ren, B. and Zhang, K.-S.*, Sensitive and Versatile Detection of the Fouling Process and Fouling Propensity of Proteins on Polyvinylidene Fluoride Membranes via Surface-Enhanced Raman Spectroscopy. Anal. Chem.2011, 83(5), 1709-1716.
34. Cui, L.*, Chen, S.D. and Zhang, K.S.*, 2015. Effect of toxicity of Ag nanoparticles on SERS spectral variance of bacteria. Spectroc. Acta Pt. A-Molec. Biomolec. Spectr. 137(0), 1061-1066.
35. Cui, L., Wu, D.Y., Wang, A., Ren, B*. and Tian, Z.Q., 2010. Charge-Transfer Enhancement Involved in the SERS of Adenine on Rh and Pd Demonstrated by Ultraviolet to Visible Laser Excitation. J. Phys. Chem. C 114(39), 16588-16595.
36. Cui, L., Ren, B.* and Tian, Z.Q., 2010. Surface-Enhanced Raman Spectroscopic Study on the Co-adsorption of DNA Bases with Perchlorate. Acta Physico-Chimica Sinica 26(2), 397-402.
37. Cui, L., Mahajan, S., Cole, R.M., Soares, B., Bartlett, P.N., Baumberg, J.J., Hayward, I.P., Ren, B., Russell, A.E*. and Tian, Z.Q., 2009. UV SERS at well ordered Pd sphere segment void (SSV) nanostructures. Phys. Chem. Chem. Phys. 11(7), 1023-1026.
38. Cui, L., Wang, A., Wu, D.Y., Ren, B*. and Tian, Z.Q*., 2008. Shaping and Shelling Pt and Pd Nanoparticles for Ultraviolet Laser Excited Surface-Enhanced Raman Scattering. J. Phys. Chem. C 112(45), 17618-17624.
39. Cui, L., Liu, Z., Duan, S., Wu, D.Y., Ren, B*., Tian, Z.Q. and Zou, S.Z., 2005. Orientation change of adsorbed pyrazine on roughened rhodium electrodes as probed by surface-enhanced Raman spectroscopy. J Phys Chem B 109(37), 17597-17602.
1.国家自然科学基金-优秀青年科学基金（21922608），基于拉曼光谱的环境生物分析，2020.1-2022.12，130万，在研，主持
2. 国家自然科学基金重大研究计划-培育项目（91851101），基于单细胞拉曼-15N2稳定同位素标记解析水圈固氮微生物及其固氮活性，2019.1-2021.12, 80万，在研，主持
3. 国家自然科学基金面上项目（21777154），基于单细胞拉曼-重水标记的环境抗生素抗性菌识别和抗性产生过程研究，2018.1-2021.12，65万，主持
4. 国家自然科学基金面上项目（21173208）,表面增强拉曼光谱原位研究滤膜表面生物膜的形成机制及影响因素, 2012.1—2015.12，60万，主持。
5. 国家自然科学青年基金（20903076）, 膜生物反应器膜污染的表面增强拉曼光谱原位检测方法建立和形成机制研究, 2010.1—2012.12, 19万，主持。
6. 国家重点研发计划项目子课题（2017YFD0200201），肥料磷在我国南方土壤中的转化过程及机制，2017.7-2020.12，90万，子课题负责人；
7. 中科院青年创新促进会会员基金, 2014. 1-2017. 12, 50万，主持。
8. 福建省自然科学基金面上项目, “基于表面增强拉曼光谱的碳纳米材料对生物膜毒性机制的原位研究”, 2015. 4-2018. 4, 项目负责人。
9. 宁波市自然科学基金, “基于表面增强拉曼光谱的碳纳米材料抗菌机制研究”, 2014. 4 - 2016. 3, 项目负责人。
10. 福建省自然科学青年基金,”表面增强拉曼光谱在膜污染微观形成机制中的应用研究” (Grand No. 2009J05032)，2009.5-2011.12,项目负责人。
