The combined pollution of heavy metals and microplastics is common in natural soil environments. Here, we collected 790 data sets from 39 studies to investigate the effects of microplastics on heavy metal bioavailability. The results showed that microplastics could increase the bioavailability of Cu, Pb, Cd, Fe, and Mn. The heavy metal bioavailability was positively correlated with microplastic size, soil sand concentration, and exposure time, but negatively correlated with soil pH and organic matter. The bioavailability of heavy metals can be promoted by microplastics of all shapes. Hydrolysable microplastics, which contain N, might have less influence. Furthermore, the size of microplastics and soil organic matter were positively correlated with the acid-soluble and reducible fractions of heavy metals, while the microplastic concentration, soil pH, and exposure time were positively correlated with the oxidizable fractions of heavy metals. The interaction detector results indicated that there was an interaction between microplastic characteristics, especially polymer types, and soil physicochemical indexes on the bioavailability of heavy metals. These findings suggested that long-term combined pollution of microplastics and heavy metals might increase heavy metal bioavailability in soils, thereby extending their migratory and hazardous range and bringing further risks to the environment and public health safety.